DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.

6 SNPs from RRM2B and UBR5 were added to this list because they are both members of GO:6281 “DNA Repair” (which, although nominally significant in GeM, did not reach q < 0.05 and was therefore not used to create the pathway cluster), both lie within a genome‐wide significant association peak in GeM‐HD, and both have significant gene‐wide p values (see Table S5 of the GeM‐HD article). 6 For each gene, the most significant SNP was selected, along with a small number of proxy SNPs in close LD ( r 2 > 0.8) with the most significant SNP that also showed association in GeM‐HD.

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