Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels.

S1A), this difference did not reach statistical significance (number of LH pulses per 8‐h: 4·3 ± 1·1, vehicle; 5·5 ± 1·8 kisspeptin‐54 0·1 nmol/kg/h; 6·0 ± 1·3 kisspeptin‐54 0·3 nmol/kg/h; 6·0 ± 0·7 kisspeptin‐54 1·0 nmol/kg/h).

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The results suggest there was a highly significant relationship between baseline oestradiol and mean LH for the 0·3 and 1·0 nmol/kg/h groups as shown in Table 2 (regression coefficients and P ‐value for the change in mean LH for a 100 pmol/l rise in baseline oestradiol: −0·25, P = 0·26, vehicle; −1·75, P = 0·24, 0·1 nmol/kg/h; 0·83, P = 0·03, 0·3 nmol/kg/h; 1·00, P = 0·03, 1·0 nmol/kg/h).

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