For the first time, in a large sample of over 41,000 individuals of European descent, the investigation of this region, by using imputation genotypes for all SNPs across this locus from the 1000 Genomes Project and repeating meta-analysis, a highly significant association was identified between smoking quantity and the rs55853698 SNP.
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Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.
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In addition, a nominally significant association of this SNP with FTND was found.