44,45 Overexpression of WAVE1-A and WAVE1-B (but not WAVE1-C) showed a trend toward increasing the expression of embryonic genes, while knockdown of WAVE1 in embryos through MO-injections caused a downregulation of many genes, including hox genes, indicating that nuclear WAVE1 plays a role in embryonic development ( Fig. 2G ). 45 Co-immunoprecipitation experiments with nuclear extracts of an NLS-WAVE1–A or –B fusion protein were conducted to identify nuclear WAVE1 interactors.
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Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities.
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