Evidence Suggesting That Francisella tularensis O-Antigen Capsule Contains a Lipid A-Like Molecule That Is Structurally Distinct from the More Abundant Free Lipid A.

When results from three capsule isolations were analyzed and compared to that of the three EtOHp preparations from which the purified HMW O-Ag capsule was derived, the compositional FA differences were again observed, including: increased presence in capsule of 3-OH-16:0 ( Fig 3G , left; p<0.05) and C14:0 ( Fig 3G , center, did not reach statistical significance) and decreased presence of C16:0 ( Fig 3G , right; p<0.001).

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