During the study period, we observed a significant trend of increase in colorectal cancer mortality (AAPC = 1.6%, 95% CI 1.3%–1.8%; Fig. 1 ).
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Colorectal cancer mortality trends in Serbia during 1991-2010: an age-period-cohort analysis and a joinpoint regression analysis.
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In central Serbia during the period 1999–2008, colorectal cancer incidence was high and showed an increasing trend [ 22 , 25 ].