Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases.

PLoS One · 2016 · PMC4919034 · PMID 27336301

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highly significantno p-value reported

Are highly significant initial studies more reliable?

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nominally significantno p-value reported

In particular Trikalinos and colleagues analyzed 55 meta-analyses and showed that initial studies poorly predicted the presence or absence of a nominally significant effect reported by the corresponding meta-analysis [ 15 ].

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