Effects of Acute and Chronic Heavy Metal (Cu, Cd, and Zn) Exposure on Sea Cucumbers (Apostichopus japonicus).

The HK in the respiratory tree showed a trend of increase and then decrease in all the treatments except groups treated with the lowest concentration for all metals in chronic exposure test.

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Under chronic low Cu exposure (0.003 mg L −1 ), the HK activity in the intestine did not change much and there was a slight trend of increase in the CC2 group (0.005 mg L −1 ) ( Figure 3 ).

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