Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats.

Primary Outcomes Grip Strength Trajectory For female LCRs, body-weight adjusted grip strength increased at an average rate of 6.7g/month in rapamycin-treated group (p=0.036), compared to a trend of 6.7g/month decline in the placebo control group (p=0.062); and the difference was highly significant (p=0.005).

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The same trend was observed in the male rats, although it did not reach statistical significance: rapamycin-treated males experienced an average decline of 0.117 Ln(m)/month compared to 0.219 Ln(m)/month, representing a 46% reduction relative to their placebo counterparts (p=0.319) (Figure 1C, D ).

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