Telomerase Activity is Downregulated Early During Human Brain Development.

Performing a linear regression analysis we found a highly significant correlation between hTR amounts and telomerase activity ( Figure 2 , p = 0.003).

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After day 6, expression of hTR was also constant at all time points with a very low expression levels at days 0–6, and a slight trend towards an increase at longer differentiation times ( Figure 4 D).

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WT hTERT expression did not change significantly during both fetal development and in adulthood but showed a trend towards increase similar to the α-spliced hTERT at 19/20 pcw ( Figure 1 C).

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