Reduced protein synthesis in schizophrenia patient-derived olfactory cells.

We tested this by performing ‘Gene-set Enrichment Analysis' 15 with molecules implicated in translational control (corresponding to the eIF2, eIF44 and mTOR proteins and mRNA transcripts in Table 1 ) in genome-wide association data, 14 and the effect was significantly associated with schizophrenia following Bonferroni correction ( P =0.019; Supplementary Data set 5 ), and showed a trend association with bipolar disorder ( P =0.084), but not Crohn's disease or type 2 diabetes ( Supplementary Data set 5 ).

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