Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.

PLoS One · 2016 · PMC4930193 · PMID 27367604

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Exposure of mice to 0.1 and 0.25 Gy TBI showed a trend to increased levels of ROS in HSCs without reaching statistical significance. 16 O Irradiation Induced Cell Cycling and DNA Damage in HPCs and HSCs Increased ROS production can stimulate stem cell cycling and cause oxidative DNA damage, resulting in stem cell exhaustion and induction of stem cell senescence.

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