Prospective study of the UGT1A1*27 gene polymorphism during irinotecan therapy in patients with lung cancer: Results of Lung Oncology Group in Kyusyu (LOGIK1004B).

The UGT1A1 * 6 gene polymorphism is associated with severe irinotecan toxicity in Asians, which was confirmed by our study; however, our results did not reach statistical significance. 12 , 22 In patients with the UGT1A1 * 28 gene polymorphism, including both heterozygous and homozygous types, grade 3–4 leukopenia and neutropenia were observed at a significantly higher frequency compared with wild type.

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