Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy.

Although we observed an overall trend toward shorter transcripts in our data sets ( Fig. 3 ), we found only a few large-magnitude (greater than twofold) changes ( Supplemental Table S2 ).

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The overall trend of shorter transcripts in the mutants does not appear to be a consequence of developmental delay, as parallel DaPars analyses of modENCODE data sets of second to third instar larvae showed a trend toward shorter transcripts in the more mature animals ( Supplemental Fig.

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