Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy.

An exploratory multivariate analysis for association of OS showed a trend of higher expression level of miR-21 (HR=1.75 with 95% CI: 1.00–3.09, P =0.05) and for E2F1 (HR=1.57 with 95% CI: 0.89–2.77, P =0.12) associated with higher risk of death (data not shown).

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In the analysis of the association of miR-372, miR-21 and E2F1 with the extreme or outlier phenotype of PFS (progressed or died within 4 months vs >alive without progression at 12 months), only miR-21 and E2F1 were marginally statistically significant ( Table 4 ).

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