Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.

72 In intracranial SA experiments where learning is required, α6-KO mice showed a trend (although it was not significant) toward reduced nicotine SA compared with wild-type (WT) control mice. 76 These findings demonstrate that the α6 subunit in the VTA is necessary for maintaining nicotine SA.

also in 53,322 other papers

Functional studies of the β3 and α6 subunits by genetic manipulation in rodents As described above, numerous genetic studies have revealed a highly significant association between variants in the CHRNB3–CHRNA6 gene cluster and increased vulnerability to ND, 21 , 27 , 28 which generates a need to explore the underlying mechanisms.

also in 132,142 other papers