SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice.

Am J Physiol Endocrinol Metab · 2016 · PMC4935145 · PMID 27048997

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nominally significantno p-value reported

Both Ral and Las significantly increased the cortical bone thickness in the appendicular skeleton, whereas the effect of Bza was only nominally significant.

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borderline significantno p-value reported

We demonstrate that all three SERMs increase the trabecular bone mass in the axial skeleton and cortical thickness in the appendicular skeleton, although the Bza-treated group is borderline significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.