High-Fat-Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders.

High‐fat‐diet‐fed 5XFAD mice tended to have lower cerebral BDNF levels than those fed control diet (although the difference did not reach statistical significance), and had significantly less BDNF levels than wild‐type mice fed control diet ( P <0.05) and high‐fat diet ( P <0.05) (Figure 9 G).

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