Matching-adjusted indirect comparisons of efficacy of BAY 81-8973 vs two recombinant factor VIII for the prophylactic treatment of severe hemophilia A.

J Blood Med · 2016 · PMC4938137 · PMID 27445511

Europe PMC DOI

hedged sentence

0.1800

closest p · 3.6× alpha

0.1800

boldest claim

The sentences

did not reach statistical significanceP =0.18not close (p > 0.1)

After matching, the ABR difference for all bleeds did not reach statistical significance (−1.5; P =0.18), but ABRs for spontaneous and trauma bleeds in BAY 81-8973 trials remained lower with differences of −1.5 ( P <0.05) and −2.6 ( P <0.05), respectively ( Figure 3 ).

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