Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.

This subset consists of 2103 MS patients and 881 controls, and resulted in a marginally significant association with disease risk ( P = 0.046), and an odds ratio (OR) of 10.19 ( Table 1 ).

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Additional support for pathogenicity was sought from a large case-control cohort of MS patients from Europe, and, although most populations present a higher prevalence of PLG p.G420D in MS patients than controls, a nominally significant difference was observed only in the French cohort ( Table 1 ).

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