While we did observe multiple cis -eQTL genes for some top candidate SNPs, such as rs73551707, these were nominally significant compared with the nearest target gene, BMP1 ( P =1.45E−15 in aorta; 1.10E−14 in mammary artery; Supplementary Fig. 19 ; Supplementary Data 12 ).
This revealed the CARDIOGRAMplusC4D associated SNPs to cluster with other highly significant (−log P value∼75) and enriched (>10-fold) SNPs for diseases with cardiovascular and chronic inflammatory (for example, UC, Crohn's disease, RA and so on) origin and unexpected overlap with bone mineral density and Schizophrenia SNPs, which appears to be cell-type dependent ( Supplementary Figs 6 and 7 ).