Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.

Reduced amounts of lung metastasis (both in numbers and size) was also observed in animals treated with A4_7 compared to those treated with DES (Figure 8F and Supplementary Figure 5 ), although the difference did not reach statistical significance when comparing the relative area of metastases.

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