Barely Significant
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Protein adsorption onto nanoparticles induces conformational changes: Particle size dependency, kinetics, and mechanisms.

Eng Life Sci · 2016 · PMC4949706 · PMID 27478430

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quite significantno p-value reported
The change in double‐layer potential is quite significant for smaller particles than 100 nm and might therefore not be distinguishable from other factors such as interaction area and curvature.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.