Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.

Each of these additive effects were highly significant (F statistic > 60, d.f. numerator , = 1, d.f. residuals = 175, p < 6 x 10 −13 ; Fig 4 ; Table 1 ).

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In G30, the only nominally significant effect was a higher-order epistatic interaction involving all four loci, which explained 3.3% of the phenotypic variance (F statistic = 6.4, d.f. numerator , = 1, d.f. residuals = 175, p < 0.013; S2 Table ).

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