N-acetylcysteine Facilitates Self-Imposed Abstinence After Escalation of Cocaine Intake.

The trend toward a decreased breakpoint in NAC-treated LgA rats did not reach statistical significance ( F 1,15 = 2.88, p > .11), nor did the trend in the total lever presses emitted during the test ( Figure 2D ) ( F 1,15 = 2.28, p > .15); these trends cannot be attributable to differential cocaine exposure before the session or to a differential level of instrumental responding (LgA: r = −.25, R 2 = .06, p > .3 and r = −.23, R 2 = .05, p > .4; ShA: r = .22, R 2 = .05, p > 0.3 and r = .19, R 2 = .04, p > .4 for total cocaine intake and total lever presses up to the PR session, respectively).

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