Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Skin tumor growth and metastasis were not obviously affected in the absence of VEGF-D; however, the knockout mice showed a trend for reduced lymphangiogenesis in skin tumors and in the untreated skin.

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Deletion of Vegfd in mice had no significant effects on skin tumor growth; nevertheless, the KO males showed a slight trend of more papillomas and cSCCs per mouse than their WT male littermates ( Figure 2 and Supplementary Figure S2; the combined data of two separate experimental groups is presented in both figures).

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