Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.

Decreases were also observed in the noninjected paw, but this failed to reach significance, F (1, 6) = 2.927, p = .1380; Figure 2(b) .

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While there were injury-induced, immediate increases in cortical protein levels of TNF-α, F (7, 19) = 1.145, p = 0.3624; Figure 4c , and IL-10, F (7, 19) = 1.043, p = 0.4351; Figure 4d , relative to sham levels, the increases did not reach statistical significance.

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