A reduction in the percentage of dorsal proliferating progenitors was observed in homozygous mutant Sox2 fl/fl ;Nkx3.1 Cre/+ RPs, compared with Sox2 fl/+ ;Nkx3.1 Cre/+ embryos but this did not reach statistical significance ( Fig. 1 E).
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SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary.
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