LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.

Nat Commun · 2016 · PMC4960312 · PMID 27432119

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However, overexpression of kinase mutant hLRRK2 G2019S failed to induce synaptic compensation, whereas overexpression of hLRRK2 I2020T transgene showed a trend towards reduced synaptic compensation compared with wild-type hLRRK2 ( Fig. 2g and Supplementary Fig. 6i ).

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