highly significantP <0.01
Genes Related to Epigenetic Regulatory Mechanisms Regardless of treatment, a two-way ANOVA showed that the differences between hepatic and intestinal levels of expression of five target genes related to epigenetic regulatory mechanisms were statistically significant ( P <0.05) or highly significant ( P <0.01; P <0.001) ( Table 3 and S3 Table ), being in general higher in the intestine.