Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

Mol Psychiatry · 2016 · PMC4970971 · PMID 26830138

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marginally significantno p-value reported

In addition, rs72953347 in OSBPL6 (P-value = 6.36·10 −07 ) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value: 4.76·10 −07 ; rs62400067, P-value: 3.54·10 −07 ).

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highly significantno p-value reported

The APOE region (rs56131196) shows highly significant results (P-values of 3.09·10 −24 , and 3.96·10 −24 for approaches ( 1 ) and ( 2 ), respectively; 187 SNPs <0.05 for approach ( 1 ) and 283 SNPs for approach ( 2 ).

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nominally significantno p-value reported

The three EOFAD genes ( APP, PSEN1, and PSEN2 ) harbor several SNPs with nominally significant association with AD.

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