Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients.

PLoS One · 2016 · PMC4975388 · PMID 27494187

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0.0530

closest p · 1.1× alpha

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a strong trendp = 0.053so close (0.05 < p ≤ 0.1)

We found no significant differences in the protein levels of the candidate target genes in the PFC of cocaine dependent individuals, while the HPC showed a significant decrease in GluA2 (t(34) = 2.31, p = 0.027) and a strong trend toward decrease in CaMKII levels (t(35) = 1.99, p = 0.053) expression, while cdk5 remained unchanged ( Fig 5A and 5B ).

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