The highly expressed 5'isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration.

Additionally, survival analysis in TNBC patients showed a trend of better survival among patients with higher expression levels of both hsa-miR-140-3p and 5’isomiR-140-3p (Fig. 1d ); a trend that was not observed when analyzing the overall population of breast cancer patients (data not shown). 5’isomiR specifically inhibits proliferation and migration of breast cell lines In order to evaluate the biological significance of both isoforms, we carried out a set of functional assays on MCF10A, MDA-MB-231 and MDA-MB-468 cells.

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