Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity.

Sci Rep · 2016 · PMC4981892 · PMID 27516062

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Infusion of FdCyd in R6/2 brains significantly upregulated the expression of striatal Drd2 , Ppp1r1b, Rasd2, and Adora2a mRNAs and also showed a trend towards increasing Penk mRNA ( Fig. 5B ), indicating that pharmacological inhibition of DNMTs can correct transcriptional deficiencies in HD mouse brain.

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