Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter.

When the Spearman’s rank-order correlation analysis was conducted on the particle ranks while excluding CRI, a statistically significant rank-order was observed for β R CELLS versus β T BALB/c (Table 6 ; R = 1.0, p < 0.001), while β I-V CELLS versus β I BALB/c and the integrated potency estimates Iβ CELLS versus Iβ BALB/c did not show a significant trend in a correlation due to low power (Table 6 ; R = 0.8, p = 0.100).

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4a and Additional file 3 : Figure S2D; two way ANOVA, PM × Dose, p = 0.026) and remained unchanged or showed an increasing trend in A549 cells (Fig. 4b and Additional file 4 : Figure S3D; not significant).

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