Genes related to the primitive streak, such as Eomes, Otx2, Mixl1 27 and Lhx1, are strongly correlated to Brachyury and either display a negative trend in their expression or switch off altogether, in synchronization with Bry-GFP onset ( Fig. 3B ).
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Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation.
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