Lastly, the expression level (MFI) of Arg1 in GAMs was significantly decreased in the tumors of the SOCS3 −/− mice compared to SOCS3 fl/fl mice (Figure 6G ), but iNOS expression in GAMs did not reach statistical significance (Figure 6H ).
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Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma.
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