Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects.

The factors used in these analyses were defined as those that were significant ( p < 0.05) or showed a nonsignificant trend toward significance ( p < 0.25) on univariate analysis and clinically important factors such as RPA class, which was previously reported to be a prognostic factor for brain metastasis and is widely used for classification.

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The present study thus confirms that SRS or SRT for small brain metastases achieves good treatment results as an alternative to surgery ( log-rank test, maximum tumor diameter brain tumors <3 cm achieve 2-year Brain-LC of 82.8 %, p = 0.002; multivariate analysis, ≥3 cm, hazard ratio 3.81 (95 % CI: 0.95–15.3), p = 0.059 (marginally significant correlation of Brain-LC)).

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