In our hands, a nonsignificant trend toward significance of reduced circulating insulin and HOMA-IR index ( p = 0.069 and 0.093, respectively) occurred in those HER2+ BC patients with any C allele of the rs11212617 SNV treated with metformin.
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“a nonsignificant trend toward significance”
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p=0.1
In the literature
The difference between logographeme and phonological information showed a nonsignificant trend toward significance (paired t 18 = 1.788, P = 0.091).
The factors used in these analyses were defined as those that were significant ( p < 0.05) or showed a nonsignificant trend toward significance ( p < 0.25) on univariate analysis and clinically important factors such as RPA class, which was previously reported to be a prognostic factor for brain metastasis and is widely used for classification.
Analysis of these three trials revealed a nonsignificant trend toward significance in favor of the NAC treatment group over the control group (SMD, −0.40; 95% CI, −0.83 to 0.03).
When we compared the adverse events which occurred, sleep disturbance showed a nonsignificant trend toward significance in the split regimen group, while more cases of nausea and vomit were reported for the patients who took the same-day preparation.