Vaccine-Mediated Activation of Human TLR4 Is Affected by Modulation of Culture Conditions during Whole-Cell Pertussis Vaccine Preparation.

PLoS One · 2016 · PMC4993483 · PMID 27548265

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a clear trendno p-value reported

pertussis bacteria harvested after the addition of sulfate (vaccine B-E) displayed a clear trend towards lower hTLR4 activation than our reference vaccine derived from this bacterial culture before sulfate was added (vaccine A ref ), we wanted to gain more insight into the relative contribution of hTLR4- and hTLR2-mediated signalling to overall vaccine-induced activation of APC.

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