High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients.

Each additional year at diagnosis translated into a 1 % lower risk of carrying BRCA1 mutations and a 1 % higher risk of harboring BRCA2 mutations, but differences did not reach statistical significance (Ratio of the probability of carrying BRCA1/2 mutations (RP) = 0.99; 95 % CI 0.97–1.01; P = 0.34 and RP = 1.01; 95 % CI 0.97–1.05; P = 0.56), respectively (Table 4 ).

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