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ADAM17 and EGFR regulate IL-6 receptor and amphiregulin mRNA expression and release in cigarette smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD).

Physiol Rep · 2016 · PMC5002905 · PMID 27561911

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Interestingly, after CS induction, COPD cells expressed full‐ILR and AREG at lower levels on average but this did not reach statistical significance (Fig. 3 D and F).

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