Treatment of Elderly Patients with Squamous Cell Carcinoma of the Head and Neck.

However, in the two cisplatin-based concurrent chemoradiation studies (RTOG 0129 and 0522), the elderly patients experienced significantly more grade 3–5 thrombocytopenia ( p = 0.02), anemia ( p = 0.03), nephrotoxicity ( p = 0.01), and ototoxicity (borderline significant; p = 0.06) than the younger patients, whereas surprisingly, severe mucositis occurred significantly less frequently in the elderly patients ( p = 0.04).

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Unfortunately, the survival benefit of nivolumab observed in patients aged 65–74 years did not reach statistical significance (HR, 0.93; 95% CI, 0.56–1.54), which was thus limited to their younger counterparts ( 104 ).

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