Notably, fluvastatin showed a trend to more beneficial effects when compared with the six other statins, namely, atorvastatin (RR 0.94, 95% CI 0.44–1.95), simvastatin (RR 0.81, 95% CI 0.38–1.64), cerivastatin (RR 0.77, 95% CI 0.19–3.16), pravastatin (RR 0.76, 95% CI 0.34–1.61), lovastatin (RR 0.68, 95% CI 0.27–1.64) and rosuvastatin (RR 0.60, 95% CI 0.28–1.37), albeit with no statistical significance achieved.
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Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma.
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Specifically, meta-analysis of the direct comparisons showed that usage of atorvastatin (OR 0.63, 95% CI 0.45- 0.89) and fluvastatin (OR 0.58, 95% CI 0.40- 0.85) could cut the risk of liver cancer, while other types of statin failed to suggest a borderline significant efficacy compared with observation alone.