Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study.

PLoS One · 2016 · PMC5008632 · PMID 27584680

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hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

In the Benjamini-Hochberg FDR tests, all of the observed significant interactions were substantially reduced and we found borderline significant interactions for VDR rs1544410 ( Bsm1 , p = 0.06), rs731236 ( Taq1 , p = 0.06), rs7975232 ( Apa1 , p = 0.06) and AGT rs699 (p = 0.06).

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borderline significancep<0.1so close (0.05 < p ≤ 0.1)

After incorporating interactions between bone lead and genotypes into the models, we found that 5 and 4 polymorphisms reached statistical significance (p<0.05) and borderline significance (p<0.1), respectively, when genotypes were modeled as additive ( Table 3 ).

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a decreasing trendno p-value reported

1.62 (95%CI: 1.23–2.14), 1.43 (95%CI: 1.17–1.75), 2.17 (95%CI: 1.51–3.12) and 1.57 (95%CI: 1.27–1.94), respectively, for HMOX1 rs5995098, APOE rs429358, AGT rs699 and rs5046, as well as a decreasing trend.

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reached borderline significanceno p-value reported

Using the dominant genetic model, 4 polymorphisms reached statistical significance and 3 reached borderline significance.

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an increasing trendno p-value reported

We also detected an increasing trend in HRs across tertiles of GRS (p-trend = 0.0063).

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