A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials.

Pharmacogenomics J · 2017 · PMC5009007 · PMID 26927285

Europe PMC DOI

hedged sentences

0.0019

closest p · 0.0× alpha

0.1200

boldest claim

The sentences

of borderline significanceP = 0.0019actually significant

In regards to the APOL1 region and fluid loss, the association remained below our significance threshold for rare variants (0.00109) in the random effects meta-analysis conducted in the entire population ( P = 0.0008), was of borderline significance in the fixed effects model in the entire population ( P = 0.0019), as well as both models limited to only Caucasians (fixed: P = 0.0013, random: P = 0.002).

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did not reach statistical significanceP = 0.12not close (p > 0.1)

The association between rs17268282 did not reach statistical significance with regards to the net fluid loss endpoint ( P = 0.12).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.