Numbers of TRAP positive osteoclasts in the rats that had received intra-articular injection of MIA and either preventative or therapeutic treatments with muMab 911 or vehicle were positively associated with weight-bearing asymmetry (standardised beta = 0.35, P = 0.04), but the association with PWT did not reach statistical significance (aOR = 1.04, 95% CI = 0.997 to 1.075, P = 0.07).
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The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.
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