A SCN10A SNP biases human pain sensitivity.

Mol Pain · 2016 · PMC5011395 · PMID 27590072

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highly significantno p-value reported

In summary, the D-PPT and S-PPT in subjects homozygous for the minor allele rs6795970 were 30% higher than in subjects with the other genotypes, with a highly significant BONF P -value reaching 2.3 × 10 −5 .

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did not reach statistical significanceno p-value reported

The peak persistent current (13.5% ± 0.7%, n = 20) for Nav1.8-Val1073 channels was reduced compared to that for Nav1.8-Ala1073 channels (15.5% ± 1.0%, n = 28); however, this difference did not reach statistical significance.

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