A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model.

PLoS One · 2016 · PMC5014419 · PMID 27603665

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0.0640

closest p · 1.3× alpha

0.0640

boldest claim

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did not reach statistical significanceP = 0.064so close (0.05 < p ≤ 0.1)

Cardiac MRI performed 4 weeks after IR injury showed that treatment with pitavastatin-NP (16 mg/body of pitavastatin) tended towards an improvement in the left ventricular ejection fraction, although these results did not reach statistical significance: 50.1 ± 5.0% in the pitavastatin-NP group and 41.8 ± 9.3% in the saline group (P = 0.064, n = 6–7 each) ( Table 1 , Fig 2A ).

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