The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.

Similarly, individuals who were high responders for IgG3 to PfRH5 had a 65% decreased risk of symptomatic falciparum malaria compared to those who were classified as low responders, after adjustment for confounders; there was also a reduced risk of malaria for high IgG1 responders, but this did not reach statistical significance (IgG3: aHR 0.35, CI: 0.17–0.71, p = 0.03; and IgG1 aHR 0.46, CI: 0.16–1.29, p = 0.14) ( Table 2 ).

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